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Notes on the strange biology already inside us.

About / a reader with a pencil

The strange part is how close to home it is

Alien Peptides is an atlas I have pieced together from published research, with strange biology to explore and no medical advice to offer. A calf’s thymus and a cell’s mitochondria are wonderfully ungrand starting places.

A name that made me look closer

The name Alien Peptides suggested distance. The research kept bringing me inward: a thymus extract, mitochondrial instructions, a fragment based on stomach-fluid biology, an engineered gut-hormone mimic. Those are origins worth lingering over. A catalogue of supposed benefits flattens the thing I enjoy most: the distance between where a molecule was found and what someone later asked it to do.

My curiosity runs towards provenance. A purified thymus peptide, a message encoded in mitochondrial DNA and a synthetic hormone mimic have different beginnings, even when each is called a peptide. I suspect the word does too much work when it makes those beginnings disappear.

The awkward landmark

The larger thymosin alpha-1 trial did not confirm the survival benefit suggested by an earlier result. That interruption deserves as much room as the 1977 discovery. I would be bored by a history in which every new experiment merely congratulated the previous one.

Cells in a dish, mice in a physical-performance test and adults in a survival trial occupy different ground. The subjects define the scope of the result. A blood measurement taken from people has a human population, but it can still be only a marker study; there may have been no treatment to compare.

None of those origins makes a missing result less important. The reading list contains experiments, reviews and trials, each with questions it was never designed to settle.

The boundary of this project

These pages are not medical advice. They do not diagnose, choose a treatment, set an amount or schedule, or replace an assessment of an individual’s health. Community accounts are anecdotal accounts, not clinical evidence. A plausible mechanism cannot supply a demonstrated human outcome.

Unknown risks remain unknown, and a study cannot establish what is in a separate research product. The contact page is for corrections, source questions and trouble reading the site. I welcome an exact sentence and a paper that challenges it; personal health records are not needed.